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Mecanismos psicobiológicos de la cognición y la conducta: Desarrollo de nuevos tratamientos para mejorar la cognición y prevenir o paliar el deterioro cognitivo.
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  • Mecanismos psicobiológicos de la cognición y la conducta: Desarrollo de nuevos tratamientos para mejorar la cognición y prevenir o paliar el deterioro cognitivo.

Esta es una línea de investigación básica en el área de la Psicobiología de la Cognición. Utilizando modelos animales investigamos los procesos psicobiológicos implicados en el aprendizaje y la memoria. El objetivo de esta investigación es encontrar y desarrollar nuevas herramientas farmacológicas para mejorar la cognición y prevenir o paliar el deterioro cognitivo.

Artículos de investigación recientes publicados en esta línea de investigación:

  • Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type Life science alliance, Vol. 6, Núm. 6
  • Effects of long-term individual housing of middle-aged female Octodon degus on spatial learning and memory in the Barnes maze task Frontiers in Behavioral Neuroscience, Vol. 17
  • Milk fat globule membrane concentrate as a nutritional supplement prevents age-related cognitive decline in old rats: A lipidomic study of synaptosomes Food Research International, Vol. 163
  • Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults Journal of Functional Foods, Vol. 111
  • Prevention of neurotoxicity and cognitive impairment induced by zinc nanoparticles by oral administration of saffron extract
  • Sánchez-Puelles, C., Calleja-Felipe, M., Ouro, A., Bougamra, G., Arroyo, A., Diez, I., Erramuzpe, A., Cortés, J., Martínez-Hernández, J., Luján, R., Navarrete, M., Venero, C., Chan, A., Morales, M., Esteban, J. A., Knafo, S. (2020). PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior. Cerebral Cortex 30(2), 505–524. https://doi.org/10.1093/cercor/bhz103
  • García-Serrano A, Tomé-Carneiro J, Carmen Crespo M, Visitación Calvo M, Pereda-Pérez I, Baliyan S, Burgos-Ramos E, Montero O, Dávalos A, Venero C, Visioli F, Fontecha J. (2020). Concentrates of buttermilk and
    krill oil improve cognition in aged rats. Prostaglandins Leukot Essent Fatty Acids. 155:102077. doi: 10.1016/j.plefa.2020.102077.
  • Pereda-Pérez, I., Valencia, A., Baliyan, S., Núñez, Á., Sanz-García, A., Zamora, B., Rodríguez-Fernández, R., Esteban, J.A., Venero, C. (2019). Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. Neurobiology of Aging. 78:155-165. https://doi.org/10.1016/j.neurobiolaging.2019.02.011
  • Gabandé‐Rodríguez, E., Pérez‐Cañamás, A., Soto‐Huelin, B., Mitroi, D.N., Sánchez-Redondo, S., Martínez‐Sáez, E., Venero, C., Peinado, H., Ledesma, M.D. (2019). Lipid‐induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders. The EMBO Journal. 38(2):e99553. https://doi.org/10.15252/embj.201899553
  • Crespo, M. C., Tomé-Carneiro, J., Gómez-Coronado, D., Burgos-Ramos, E., Garciá-Serrano, A., Martín-Hernández, R., Baliyan, S., Fontecha, J., Venero, C., Dávalos, A., Visioli, F. (2018). Modulation of miRNA expression in aged rat hippocampus by buttermilk and krill oil. Scientific Reports. 8(1):3993 https://doi.org/10.1038/s41598-018-22148-5
  • Tomé-Carneiro, J., Carmen Crespo, M., Burgos-Ramos, E., Tomas-Zapico, C., García-Serrano, A., Castro-Gómez, P., Venero, C., Pereda-Pérez, I., Baliyan, S., Valencia, A., Fontecha, J., Dávalos, A., Visioli, F. (2018). Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats. Molecular Neurobiology. 55(9):7285-7296.
    https://doi.org/10.1007/s12035-018-0934-y
  • Bárez-López S, Montero-Pedrazuela A, Bosch-García D, Venero C, Guadaño-Ferraz A. (2017). Increased anxiety and fear memory in adult mice lacking type 2 deiodinase. Psychoneuroendocrinology. 84:51-60. doi: 10.1016/j.psyneuen.2017.06.013
  • Palomer, E., Martín-Segura, A., Baliyan, S., Ahmed, T., Balschun, D., Venero, C., Martin, M. G., Dotti, C. G. (2016). Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons. Cell Reports, 16(11):2889-2900.
    https://doi.org/10.1016/j.celrep.2016.08.028
  • Sanz-García, A., Knafo, S., Pereda-Pérez, I., Esteban, J. A., Venero, C., Armario, A. (2016). Administration of the TrkB receptor agonist 7,8-dihydroxyflavone prevents traumatic stress-induced spatial memory deficits and changes in synaptic plasticity. Hippocampus, 26(9):1179-88. https://doi.org/10.1002/hipo.22599
  • Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber
    EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R,
    Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA. (2016). PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nat Neurosci.;19(3):443-53. doi: 10.1038/nn.4225
  • Palomer E, Martín-Segura A, Baliyan S, Ahmed T, Balschun D, Venero C, Martin MG, Dotti CG. (2016). Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal
    Neurons. Cell Rep. Sep 13;16(11):2889-2900. doi:
    10.1016/j.celrep.2016.08.028.
  • Martin MG, Ahmed T, Korovaichuk A, Venero C, Menchón SA, Salas I, Munck S, Herreras O, Balschun D, Dotti CG. (2014).
    Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents. EMBO Mol Med.;6(7):902-17. doi: 10.15252/emmm.201303711.
  • Cruces J, Venero C, Pereda-Pérez I, De la Fuente M. (2014). The effect of psychological stress and social isolation on neuroimmunoendocrine communication. Curr Pharm Des. ;20(29):4608-28. doi: 10.2174/1381612820666140130205822.
  • Cruces J, Venero C, Pereda-Pérez I, De la Fuente M. (2014). A higher anxiety state in old rats after social isolation is associated to
    an impairment of the immune response. J Neuroimmunol. 15;277(1-2):18-25. doi: 10.1016/j.jneuroim.2014.09.011
  • Ecay-Torres, M., Estanga, A., Tainta, M., Izagirre, A., García-Sebastian, M., Villanua, J., Clerigue, M., Iriondo, A., Urreta, I., Mar; J., Diaz-Mardomingo, MC., Kivipelto, M., Martinez-Lage, P. (2018). Increased CAIDE dementia risk, cognition, CSF biomarkers and vascular burden in healthy subjects. Neurology, 0:1-10. doi: https://doi.org/10.1212/WNL.0000000000005824. Impact Factor: 8.249 (2016 Journal Citation Reports® 2017). Q1 en Neuroscience & Behavior.
  • Díaz-Mardomingo, M.C., García-Herranz, S., Rodríguez-Fernández, R., Venero, C., Peraita, H. (2017). Classificatory problems in Mild Cognitive Impairment (MCI). One or multiple syndromes? Brain Sciences, 7, 111; doi: 10.3390/brainsci7090111. Impact Factor (Scopus): 2.57.
  • Díaz-Mardomingo, M.C., García-Herranz, S., Rodríguez-Fernández, R., Venero, C., Peraita, H. (2017). Classificatory problems in Mild Cognitive Impairment (MCI). One or multiple syndromes? Brain Sciences, 7, 111; doi: 10.3390/brainsci7090111. Impact Factor (Scopus): 2.57.
  • Díaz-Mardomingo, C. y García, S. (2015). Prevención de situaciones de dependencia en personas mayores con deterioro cognitivo. Evaluación e intervención psicológica. En: Retos y desafíos en materia de discapacidad: una visión multidisciplinar. Ed. INAP. Cap. 7. 161-169. ISBN: 978-4-7351-501-6.
  • Peraita, H., Chacón, J. Díaz-Mardomingo, M.C y Martínez, M.R. (2015). Profiles of mild cognitive impairment (MCI) in the elderly. Spanish Journal of Psychology. doi:10.1017/sjp.2015.96 18e90. 1-12. I.I. 0.586. Impact Factor: 0.275. Q2 en General Social Sciences.
  • Knafo S, Venero C (2015). Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors. Academic Press- Elsevier. https://doi.org/10.1016/B978-0-12-417042-1.01001-9
  • Díaz Mardomingo, M.C., García Herranz, S., Márquez Flores, M.F., Silva Ventura, A.I. Peraita Adrados, H. (2014). Cuaderno de entrenamiento de memoria y otros procesos cognitivos. Editorial UNED. Madrid. Colección temática. ISBN: 978-84-362-6951-2.
  • Mariscal, S. y Díaz Mardomingo, M.C. Desarrollo y envejecimiento. (2014). En: Neurociencia cognitiva. Cap. 5. Páginas inicio: 97, final: 111. Ed. Sanz y Torres. ISBN: 978-84-15550-45-7.
  • Ortiz-Tudela, E., Martínez-Nicolás, A., Díaz-Mardomingo, C., García-Herranz, S., Pereda-Pérez, I., Valencia, A., Peraita, H., Venero, C., Madrid, J.A., Rol, M.A. (2014). The characterization of biological rhythms in mild cognitive impairment. Bio Med Research Internacional. http://dx.doi.org/10.1155/2014/524971. Impact Factor: 1.579. Q2 en Biology & Biochemistry.
  • García-Herranz, S., Díaz Mardomingo, M.C. y Peraita, H. (2014). Evaluación y seguimiento del envejecimiento sano y con deterioro cognitivo leve (DCL) a través del TAVEC. Anales de Psicología, 30, vol. 1. 372-379. doi: http://dx.doi.org/10.6018/analesps.30.1.150711.  Impact Factor: 0.504. Q3 en Psychology (Miscellaneous).
  • Venero, C., Díaz-Mardomingo, C., Pereda-Pérez, I., García, S. Utrera, L., Valencia, A., y Peraita H. (2013). Increased morning salivary cortisol levels in older adults with nonamnestic and multidomain mild cognitive impairment. Psychoneuroendocrinology. 38, 4, 488- 498. http://dx.doi.org/10.1016/j.psyneuen.2012.07.007. Impact Factor: 5,591, Q1 en Neurosciences.
  • VENERO C, KNAFO S, SÁNCHEZ-PUELLES C, PEREDA-PERÉZ I, FRANCO A, SANDI C, SUÁREZ L, SOLÍS JM, ALONSO-NANCLARES L, MARTÍN E.D., MERINOSERRAIS P, BORCEL E, LI S, CHEN Y, GONZALEZ-SORIANO J, BEREZIN V, BOCK E, DEFELIPE J, ESTEBAN J.A. (2012). Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement. PLoS Biology – Feb;10(2):e1001262
  • MONTERO-PEDRAZUELA A, FERNÁNDEZ-LAMO I, ALIEVA M, PEREDA-PÉREZ I, VENERO C, GUADAÑO-FERRAZ A. (2011). Adult-onset hypothyroidism enhances fear memory and upregulates mineralocorticoid and glucocorticoid receptors in the amygdala. PLoS One 6(10): e26582
  • KRAEV I, HENNEBERGER C, ROSSETTI C, CONBOY L, KOHLER LB, FANTIN M, JENNINGS A, VENERO C, POPOV V, RUSAKOV D, STEWART MG, BOCK E, BEREZIN V, SANDI C. (2011). Pharmacological targeting of trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus. PLoS One. 6(8): 23433
  • KRZYZANOWSKA A, PITTOLO S, CABRERIZO M, SÁNCHEZ-LÓPEZ J, KRISHNASAMY S, VENERO C, AVENDAÑO C. (2011). Assessing nociceptive sensitivity in mouse models of inflammatory and neuropathic trigeminal pain. J. Neurosci Methods. 201(1):46-54
  • VENERO C, KNAFO S, MERINO-SERRAIS P, FERNAUD-ESPINOSA I, GONZALEZ-SORIANO J, FERRER I, SANTPERE G, DEFELIPE J. (2009). Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer’s disease. Journal of Pathology – 219(1):41-51.
  • BORCEL E, PÉREZ-ALVAREZ L, HERRERO AI, BRIONNE T, VAREA E, BEREZIN V, BOCK E, SANDI C, VENERO C. (2008). Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule. Behavioral Pharmacology 19(1):41-49.
  • KNAFO S., BARKAI E., LIBERSAT F., SANDI C., VENERO, C.(2005). Dynamics of olfactory learning-induced up-regulation of L1 in the piriform cortex and the hippocampus. Eur. J. Neurosci. 21 (2): 581-586.
  • LÓPEZ-FERNANDEZ M.A., MONTARON M.F., ROUGON G., VENERO C, ABROUS D.N., SANDI C. (2007). Upregulation of Polysialylated Neural Cell Adhesion Molecule in the Dorsal Hippocampus Following Contextual Fear Conditioning is Involved in Long-Term Memory Formation. Journal of Neuroscience 27(17):4552-61.
  • RIZHOVA L., KLEMENTIEV B., CAMBON K., VENERO C., SANDI C., VERSHININA E., VAUDANO E., BEREZIN V., BOCK E. (2007). Effects of P2, a peptide derived from a homophilic binding site in NCAM, on learning and memory in rats. Neuroscience – 23;149(4):931-42.
  • VENERO C., HERRERO A.I. TOUYAROT K., CAMBON K., LÓPEZ-FERNÁNDEZ M.A., BEREZIN V., BOCK E., SANDI C. (2006). Hippocampal upregulation of NCAM expression and polysialylation plays a key role on the consolidation of spatial information.
  • LÓPEZ-GRANCHA M, LÓPEZ-CRESPO, G, VENERO, C, CAÑADAS, F., FERNANDO SÁNCHEZ-SANTED, F, SANDI, C, FLORES, P. (2006). Differences in corticosterone level due to inter-food interval length: implications for schedule-induced polydipsia. Hormones and Behavior 49(2):166-72.
  • MONTERO-PEDRAZUELA A, VENERO C, LAVADO-AUTRIC1 R, FERNÁNDEZ-LAMO I, GARCÍA-VERDUGO JM, BERNAL J, GUADAÑO-FERRAZ A. (2006). Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behaviour. Molecular Psychiatry 11(4):361-7. European Journal of Neuroscience 23(6):1585-95.
  • HERRERO A.I., SANDI C., VENERO C.(2006). Individual differences in anxiety trait are related to spatial learning abilities and hippocampal expression of mineralocorticoid receptors. Neurobiology of Learning and Memory 86(2):150-159.
  • VENERO C., GUADAÑO-FERRAZ A, HERRERO A.I., NORDSTRÖM K., MANZANO J., MOREALE-ESCOBAR G., BERNAL J., VENNSTRÖM B. (2005). Anxiety, memory impairment and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha 1 can be ameliorated by T3 treatment. Genes and Development 19 (18): 2152-2163

LIBROS

  • Sandi, C., Venero, C. and Cordero, M.I. (2001). Estrés, Memoria y Trastornos Asociados. Barcelona: Editorial Ariel (Colección Neurociencia). ISBN: 84-344-0888-0.
  • Sandi, C., Cordero, M.I. and Venero, C. (2000). Estrategias Psicológicas y Farmacológicas para el Tratamiento del Estrés. Madrid: Colección Cuadernos de la UNED. ISBN: 84-362-4115-0.

CAPITULOS EN LIBROS

    • Estrés, Envejecimiento y Deterioro Cognitivo. El reloj Biológico del envejecimiento: 1226-1230 (2002). Universidad de Murcia ISBN 84-8425-253-1
    • Modulación Emocional de la Memoria. Memoria y Cerebro. (2004). Fundación Mapfre Medicina. ISBN 84-7100-732-0

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